OTC Markets Publishes Best 50 Firms Traded in 2021

OTC Markets has published its annual ranking of the top 50 firms traded on its platform. The OTCQX Best 50 ranks the top U.S. and international companies traded on the OTCQX Best Market, based on an equal weighting of one-year total return and average daily dollar volume growth during 2021.

Jason Paltrowitz, OTC Markets Group EVP of Corporate Services, commented:

“The 2022 OTCQX Best 50 highlights a broad range of companies traded on the OTCQX Market. Much like the market itself these companies represent various sizes, geographies and sectors including mining, energy, technology, financial services and crypto. We are thrilled to see these companies grow, leveraging our regulated public markets. We congratulate this year’s roster and are proud to recognize the impressive efforts of these companies.”

The 2022 OTCQX Best 50 companies traded an aggregate $594 million in average daily dollar volume in 2021, up from $123 million in 2020.

These companies delivered to investors a median total return of 81% in 2021.

The median market cap for the companies ranked in this year’s list was just under $200 million, and among them were 9 companies with a market cap greater than $1 billion.

This year’s top-performing company, Nanalysis Scientific Corp (OTCQX: NSCIF), a Canadian developer and manufacturer of portable Nuclear Magnetic Resonance (NMR) devices for laboratory and industrial markets. Nanalysis Scientific Corp cross-trades on the TSX Venture Exchange (TSXV) in Canada under the ticker symbol ‘NSCI’ and the Frankfurt Stock Exchange under the ticker symbol ‘1N1’ also earning the ranking of the top performing international company on the 2022 OTCQX Best 50.

Ten companies from last year’s ranking made their second appearance on the OTCQX Best 50 including the following firms:

  • IsoEnergy Ltd. (OTCQX: ISENF)
  • Global Atomic Corp. (OTCQX: GLATF)
  • Neo Lithium Corp. (OTCQX: NTTHF)
  • Deep Yellow Ltd. (OTCQX: DYLLF)
  • Grayscale Digital Large Cap Fund LLC (OTCQX: GDLC)
  • Converge Technology Solutions Corporation (OTCQX: CTSDF)
  • POET Technologies Inc. (OTCQX: POETF)
  • H2O Innovation Inc. (OTCQX: HEOFF)
  • Nanoxplore Inc. (OTCQX: NNXPF)
  • Grayscale Bitcoin Trust (BTC) (OTCQX: GBTC)
  • Adventus Mng Corp. (OTCQX: ADVZF)

The top fifty firms trade on OTCQX are listed below:

Rank Company Symbol
1 Nanalysis Scientific Corp. (OTCQX: NSCIF)
2 Constantine Metal Resources Ltd. (OTCQX: CNSNF)
3 InPlay Oil Corp. (OTCQX: IPOOF)
4 Filo Mining Corp. (OTCQX: FLMMF)
5 Journey Energy Inc. (OTCQX: JRNGF)
6 Opsens, Inc. (OTCQX: OPSSF)
7 Grayscale Ethereum Trust (ETH) (OTCQX: ETHE)
8 IsoEnergy Ltd. (OTCQX: ISENF)
9 Corsa Coal Corp. (OTCQX: CRSXF)
10 Obsidian Energy Ltd. (OTCQX: OBELF)
11 Global Atomic Corp. (OTCQX: GLATF)
12 Neo Lithium Corp. (OTCQX: NTTHF)
13 NOVONIX LTD. (OTCQX: NVNXF)
14 Petrus Resources Ltd. (OTCQX: PTRUF)
15 Grayscale Ethereum Classic Trust (ETC) (OTCQX: ETCG)
16 Wow Unlimited Media Inc. (OTCQX: WOWMF)
17 Labrador Gold Corp. (OTCQX: NKOSF)
18 Western Uranium & Vanadium Corp. (OTCQX: WSTRF)
19 Eloro Resources Ltd. (OTCQX: ELRRF)
20 Taal Distributed Information Technologies Inc. (OTCQX: TAALF)
21 Deep Yellow Ltd. (OTCQX: DYLLF)
22 Torq Resources Inc. (OTCQX: TRBMF)
23 Bombardier Inc. (OTCQX: BDRBF, BDRAF)
24 Coastal Carolina Bancshares Inc (OTCQX: CCNB)
25 Fission Uranium Corp. (OTCQX: FCUUF)
26 Grayscale Digital Large Cap Fund LLC (OTCQX: GDLC)
27 Indiva Ltd. (OTCQX: NDVAF)
28 Millennial Lithium Corp. (OTCQX: MLNLF)
29 Converge Technology Solutions Corporation (OTCQX: CTSDF)
30 POET Technologies Inc. (OTCQX: POETF)
31 4Front Ventures Corp. (OTCQX: FFNTF)
32 Amerigo Resources Ltd. (OTCQX: ARREF)
33 Enzon Pharmaceuticals, Inc. (OTCQX: ENZN)
34 Yankuang Energy Group Co Ltd. (OTCQX: YZCAY, YZCHF)
35 ASM International N.V. (OTCQX: ASMIY)
36 NioCorp Developments Ltd. (OTCQX: NIOBF)
37 Thunderbird Entertainment Group Inc. (OTCQX: THBRF)
38 SVB&T Corporation OTCQX: SVBT)
39 Nuvo Pharmaceuticals Inc (OTCQX: MRVFF)
40 Unrivaled Brands, Inc. (OTCQX: UNRV)
41 GOODNESS GROWTH HLDGS INC. (OTCQX: GDNSF)
42 Ivanhoe Mines Ltd. (OTCQX: IVPAF)
43 H2O Innovation Inc. (OTCQX: HEOFF)
44 Nanoxplore Inc. OTCQX: NNXPF)
45 Grayscale Bitcoin Trust (BTC) (OTCQX: GBTC)
46 Corning Natural Gas Holding Corporation (OTCQX: CNIG, CNIGO, CNIGP)
47 Table Trac, Inc. (OTCQX: TBTC)
48 MariMed Inc. (OTCQX: MRMD)
49 Adventus Mng Corp. (OTCQX: ADVZF)
50 GrandSouth Bancorporation (OTCQX: GRRB)


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Reg A - Form 1-A Filings Beta

Beta. Initial Form 1-A only. Target raise is the stated Amount to be Raised, totaled. Compared with the same dates one year earlier.

YTD: Jan 1, 2026 - Oct 29, 2026 vs Jan 1, 2025 - Oct 29, 2025

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Number of Filings132Prior 128 +3.1%
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This YTDYear priorChange
Filings 132 128 +3.1%
Target raise $3.44B $3.56B -3.5%

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